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CD8 CDKN2A-/- lymphocytes expressing an active form of the transcription factor Stat5

ABSTRACT: Transcriptome analyses of memory CDKN2A-/- CD8 T lymphocytes expressing an active form of the transcription factor Stat5. CDKN2A-/- CD8 T lymphocytes were activated by anti-CD3/CD28. After 40h, an active form of Stat5 was introduced in activated cells. Culture was continued for another 48h to induce their differentiation in effector T cells. These 88h activated T cells were injected in congeneic hosts and recovered 15 days later from the host spleen and lymph nodes: CDKN2A-/- Stat5ca -d15: 2 replicates– S46, S47. This study is a complement of the samples previously deposited under accession number GSE41819. Those two new samples are compared to previously deposited: - activated CD8 T lymphocytes transduced to express Stat5ca and transferred in congenic hosts: o S11 (GSM663446); o S12 (GSM663445); o S13 (GSM663444); o S14 (GSM663439). and - naive peripheral CD8 T lymphocytes : o S33 (GSM663441); o S34 (GSM663435); o S35 (GSM663449); o S36 (GSM663447).

ORGANISM(S): Mus musculus

SUBMITTER: Nathalie AUPHAN-ANEZIN 

PROVIDER: E-GEOD-56154 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Control of CD8 T cell proliferation and terminal differentiation by active STAT5 and CDKN2A/CDKN2B.

Grange Magali M   Giordano Marilyn M   Mas Amandine A   Roncagalli Romain R   Firaguay Guylène G   Nunes Jacques A JA   Ghysdael Jacques J   Schmitt-Verhulst Anne-Marie AM   Auphan-Anezin Nathalie N  

Immunology 20150615 4

CD8 T cells used in adoptive immunotherapy may be manipulated to optimize their effector functions, tissue-migratory properties and long-term replicative potential. We reported that antigen-stimulated CD8 T cells transduced to express an active form of the transcription factor signal transducer and activator of transcription 5 (STAT5CA) maintained these properties upon adoptive transfer. We now report on the requirements of STAT5CA-expressing CD8 T cells for cell survival and proliferation in vi  ...[more]

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