Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Daizo Koinuma
PROVIDER: E-GEOD-56356 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Cell research 20140725 8
Thyroid transcription factor-1 (TTF-1, also known as NKX2-1) is a tissue-specific transcription factor in lung epithelial cells. Although TTF-1 inhibits the epithelial-to-mesenchymal transition induced by transforming growth factor-β (TGF-β) in lung adenocarcinoma cells, the mechanism through which TTF-1 inhibits the functions of TGF-β is unknown. Here we show that TTF-1 disrupts the nuclear Smad3-Smad4 complex without affecting the nuclear localization of phospho-Smad3. Genome-wide analysis by ...[more]