Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Elke Cario
PROVIDER: E-GEOD-56426 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Frank Magdalena M Hennenberg Eva Maria EM Eyking Annette A Rünzi Michael M Gerken Guido G Scott Paul P Parkhill Julian J Walker Alan W AW Cario Elke E
Journal of immunology (Baltimore, Md. : 1950) 20150114 4
Intestinal mucositis represents the most common complication of intensive chemotherapy, which has a severe adverse impact on quality of life of cancer patients. However, the precise pathophysiology remains to be clarified, and there is so far no successful therapeutic intervention. In this study, we investigated the role of innate immunity through TLR signaling in modulating genotoxic chemotherapy-induced small intestinal injury in vitro and in vivo. Genetic deletion of TLR2, but not MD-2, in mi ...[more]