Unknown,Transcriptomics,Genomics,Proteomics

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Expression data from proximal jejunum of WT vs. TLR2 KO mice after methotrexate (MTX) treatment


ABSTRACT: The role of innate immunity in modulating severity of chemotherapy-induced complications is so far unclear. The aim of this study was to determine how TLR2 may influence MTX-induced mucositis in the small intestine in mice. We used microarrays to assess gene expression profiles in proximal jejunum of WT vs. TLR2 KO mice after systemic treatment with MTX. Mucositis was induced by i.p. injection of MTX [40mg/kg BW/d] for 4 days in WT or TLR2 knockout (KO) mice. On day 7, mice were sacrificed and RNA was extracted from proximal jejunum (n=3 mice/group) and hybridized on Affymetrix microarrays.

ORGANISM(S): Mus musculus

SUBMITTER: Elke Cario 

PROVIDER: E-GEOD-56426 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

TLR signaling modulates side effects of anticancer therapy in the small intestine.

Frank Magdalena M   Hennenberg Eva Maria EM   Eyking Annette A   Rünzi Michael M   Gerken Guido G   Scott Paul P   Parkhill Julian J   Walker Alan W AW   Cario Elke E  

Journal of immunology (Baltimore, Md. : 1950) 20150114 4


Intestinal mucositis represents the most common complication of intensive chemotherapy, which has a severe adverse impact on quality of life of cancer patients. However, the precise pathophysiology remains to be clarified, and there is so far no successful therapeutic intervention. In this study, we investigated the role of innate immunity through TLR signaling in modulating genotoxic chemotherapy-induced small intestinal injury in vitro and in vivo. Genetic deletion of TLR2, but not MD-2, in mi  ...[more]

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