Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: yaoyu chen
PROVIDER: E-GEOD-56492 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
The Journal of biological chemistry 20140515 27
Heat shock protein 90 (HSP90) inhibition inhibits cancer cell proliferation through depleting client oncoproteins and shutting down multiple oncogenic pathways. Therefore, it is an attractive strategy for targeting human cancers. Several HSP90 inhibitors, including AUY922 and STA9090, show promising effects in clinical trials. However, the efficacy of HSP90 inhibitors may be limited by heat shock factor 1 (HSF1)-mediated feedback mechanisms. Here, we identify, through an siRNA screen, that the h ...[more]