Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

Expression data from fine-needle aspiration biopsies of breast cancer metastases from different anatomical sites

ABSTRACT: To determine whether breast cancer molecular subtypes and tumor characteristics with demonstrated significance in a primary tumor setting can also confer clinically relevant information in breast cancer metastases. We assessed previously published gene expression modules of seven biological processes and the intrinsic subtypes (PAM50). The translational aspect of the Swedish randomized TEX trial included 112 patients with at least one biopsy from morphologically confirmed loco-regional or distant breast cancer metastasis diagnosed from December 2002 until June 2007. All patients had detailed clinical information, complete follow-up and metastasis gene expression information (Affymetrix array GPL10379). We performed global gene expression profiling on fine-needle aspirates of metastatic lesions from different anatomical sites obtained from breast cancer patients treated within the Swedish randomized trial (TEX) of first-line chemotherapy for locally advanced or metastatic breast cancer. Samples were collected before commencement of treatment.

ORGANISM(S): Homo sapiens

SUBMITTER: Nicholas Tobin 

PROVIDER: E-GEOD-56493 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

Json Xml
altmetric image

Publications

Molecular subtype and tumor characteristics of breast cancer metastases as assessed by gene expression significantly influence patient post-relapse survival.

Tobin N P NP   Harrell J C JC   Lövrot J J   Egyhazi Brage S S   Frostvik Stolt M M   Carlsson L L   Einbeigi Z Z   Linderholm B B   Loman N N   Malmberg M M   Walz T T   Fernö M M   Perou C M CM   Bergh J J   Hatschek T T   Lindström L S LS  

Annals of oncology : official journal of the European Society for Medical Oncology 20141031 1

<h4>Background</h4>We and others have recently shown that tumor characteristics are altered throughout tumor progression. These findings emphasize the need for re-examination of tumor characteristics at relapse and have led to recommendations from ESMO and the Swedish Breast Cancer group. Here, we aim to determine whether tumor characteristics and molecular subtypes in breast cancer metastases confer clinically relevant prognostic information for patients.<h4>Patients and methods</h4>The transla  ...[more]

Similar Datasets

Transcriptomics Expression data from fine-needle aspiration biopsies of breast cancer metastases from different anatomical sites
2013-12-02 | E-GEOD-46141 | biostudies-arrayexpress
Transcriptomics Expression data from fine-needle aspiration biopsies of breast cancer metastases from different anatomical sites
2014-11-03 | GSE56493 | GEO
Proteomics A common human PCSK9 germline variant drives breast cancer metastasis via the LRP1 receptor
2024-12-05 | PXD049279 | Pride
Transcriptomics Effect of host PCSK9 treatment on the gene expression of EO771 primary tumor [RNAseq_KI_tumor]
2024-12-09 | GSE273936 | GEO
Transcriptomics Effect of host PCSK9 treatment on the gene expression of EO771 primary tumor
2024-12-09 | GSE255560 | GEO
Transcriptomics Effect of Lrp1 knockdown on the gene expression of EO771 cells
2024-12-09 | GSE255559 | GEO
Transcriptomics Effect of recombinant PCSK9 treatment on the gene expression of EO771 cells
2024-12-09 | GSE255558 | GEO
Proteomics Quantitative proteomic analysis identifies TUBB2A as a novel protein biomarker for prediction of distant metastatic breast cancer
2020-06-05 | PXD016061 | Pride
Transcriptomics Expression data from fine-needle aspiration biopsies of breast cancer metastases from different anatomical sites
2013-12-02 | GSE46141 | GEO
Other Consensus molecular subtypes as biomarkers of FU/FA maintenance therapy with or without panitumumab in RAS wild-type metastatic colorectal cancer (PanaMa, AIO KRK 0212).
2023-02-15 | GSE221953 | GEO