Unknown,Transcriptomics,Genomics,Proteomics

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Expression data from fine-needle aspiration biopsies of breast cancer metastases from different anatomical sites


ABSTRACT: Breast cancer molecular subtypes preferentially metastasize to specific organs and the anatomical location of the metastasis is associated with the length of survival post-recurrence. We used microarrays to provide a detailed characterization of breast cancer site-specific metastases with particular focus on identifying genes predictive of breast cancer liver metastatic proprnsity We performed global gene expression profiling on fine-needle aspirates of metastatic lesions from different anatomical sites obtained from breast cancer patients treated within the Swedish randomized trial (TEX) of first-line chemotherapy for locally advanced or metastatic breast cancer. Samples were collected before commencement of treatment.

ORGANISM(S): Homo sapiens

SUBMITTER: Siker Kimbung 

PROVIDER: E-GEOD-46141 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Claudin-2 is an independent negative prognostic factor in breast cancer and specifically predicts early liver recurrences.

Kimbung Siker S   Kovács Anikó A   Bendahl Pär-Ola PO   Malmström Per P   Fernö Mårten M   Hatschek Thomas T   Hedenfalk Ingrid I  

Molecular oncology 20131014 1


<h4>Background</h4>Predicting any future metastatic site of early-stage breast cancer is important as it significantly influences the prognosis of advanced disease. This study aimed at investigating the potential of claudin-2, over-expressed in breast cancer liver metastases, as a biomarker for predicting liver metastatic propensity in primary breast cancer.<h4>Methods</h4>Claudin-2 expression was analyzed in two independent cohorts. Cohort 1 included 304 women with metastatic breast cancer diag  ...[more]

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