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Activating transcription factor 6 is necessary and sufficient for alcoholic fatty liver disease in zebrafish

ABSTRACT: ATF6 is a key regulator of the unfolded protein response. Through use of zebrafish and cultured cells we demonstrate that ATF6 drives fatty liver disease by interaction with fatty acid synthase (FASN). Total small RNA from livers of 5 dpf larval zebrafish were collected: 2 batches of Tg(fabp10:nls-mCherry) control larvae, 2 batches of ethanol-treated Tg(fabp10:nls-mCherry) larvae, and 1 batch of Tg(fabp10:nAtf6-cherry; cmlc2:GFP). Each batch was purified for preparation of high-throughput sequencing libraries.

ORGANISM(S): Danio rerio

SUBMITTER: Ravi Sachidanandam

PROVIDER: E-GEOD-56498 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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