Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of lesional and non-lesional skin from actopic dermititis patients and normal skin

ABSTRACT: Atopic dermatitis (AD) is a common pruritic dermatitis with macroscopically nonlesional skin that is often abnormal. Therefore, we used high-density oligonucleotide arrays to identify cutaneous gene transcription changes associated with early AD inflammation as potential disease control targets. Skin biopsy specimens analyzed included normal skin from five healthy nonatopic adults and both minimally lesional skin and nearby or contralateral nonlesional skin from six adult AD patients. Keywords: disease state analysis We used high-density oligonucleotide Affymetrix Human U133A GeneChip arrays to identify cutaneous gene transcription changes associated with early AD inflammation as potential disease control targets. Skin biopsy specimens analyzed included normal skin from five healthy nonatopic adults and both minimally lesional skin and nearby or contralateral nonlesional skin from six adult AD patients.

ORGANISM(S): Homo sapiens

SUBMITTER: Douglas Plager 

PROVIDER: E-GEOD-5667 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Early cutaneous gene transcription changes in adult atopic dermatitis and potential clinical implications.

Plager Douglas A DA   Leontovich Alexey A AA   Henke Susan A SA   Davis Mark D P MD   McEvoy Marian T MT   Sciallis Gabriel F GF   Pittelkow Mark R MR  

Experimental dermatology 20070101 1

Atopic dermatitis (AD) is a common pruritic dermatitis with macroscopically non-lesional skin that is often abnormal. Therefore, we used high-density oligonucleotide arrays to identify cutaneous gene transcription changes associated with early AD inflammation as potential disease control targets. Skin biopsy specimens analysed included normal skin from five healthy non-atopic adults and both minimally lesional skin and nearby or contralateral non-lesional skin from six adult AD patients. Data we  ...[more]

PMID: 17181634

Publication: 1/2

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