Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Hee-Woong Lim
PROVIDER: E-GEOD-56747 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Step Sonia E SE Lim Hee-Woong HW Marinis Jill M JM Prokesch Andreas A Steger David J DJ You Seo-Hee SH Won Kyoung-Jae KJ Lazar Mitchell A MA
Genes & development 20140501 9
Rosiglitazone (rosi) is a powerful insulin sensitizer, but serious toxicities have curtailed its widespread clinical use. Rosi functions as a high-affinity ligand for peroxisome proliferator-activated receptor γ (PPARγ), the adipocyte-predominant nuclear receptor (NR). The classic model, involving binding of ligand to the NR on DNA, explains positive regulation of gene expression, but ligand-dependent repression is not well understood. We addressed this issue by studying the direct effects of ro ...[more]