Unknown,Transcriptomics,Genomics,Proteomics

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Antidiabetic Rosiglitazone Remodels the Adipocyte Transcriptome by Redistributing Transcription to PPARg-Driven Enhancers


ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Mus musculus

SUBMITTER: Hee-Woong Lim 

PROVIDER: E-GEOD-56747 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Anti-diabetic rosiglitazone remodels the adipocyte transcriptome by redistributing transcription to PPARγ-driven enhancers.

Step Sonia E SE   Lim Hee-Woong HW   Marinis Jill M JM   Prokesch Andreas A   Steger David J DJ   You Seo-Hee SH   Won Kyoung-Jae KJ   Lazar Mitchell A MA  

Genes & development 20140501 9


Rosiglitazone (rosi) is a powerful insulin sensitizer, but serious toxicities have curtailed its widespread clinical use. Rosi functions as a high-affinity ligand for peroxisome proliferator-activated receptor γ (PPARγ), the adipocyte-predominant nuclear receptor (NR). The classic model, involving binding of ligand to the NR on DNA, explains positive regulation of gene expression, but ligand-dependent repression is not well understood. We addressed this issue by studying the direct effects of ro  ...[more]

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