Dataset Information
Identification of a novel NF-kB target gene in human triple-negative breast cancer cells
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Satoshi Kondo
PROVIDER: E-GEOD-56812 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Tropomodulin 1 expression driven by NF-κB enhances breast cancer growth.
Cancer research 20141114 1
Triple-negative breast cancers (TNBC), which include the basal-like and claudin-low disease subtypes, are aggressive malignancies for which effective therapeutic targets are lacking. NF-κB activation has an established role in breast malignancy, and it is higher in TNBC than other breast cancer subtypes. On this basis, we hypothesized that proteins derived from NF-κB target genes might be molecular targets for TNBC therapy. In this study, we conducted a microarray-based screen for novel NF-κB-in ...[more]
