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SUV420H2 over-expression affects on gene expression in human breast cancer MDA-MB-231 cells [MAA13355]

ABSTRACT: Analysis of breast cancer MDA-MB-231 cells stably over-expressing SUV420H2, a histone H4K20 methyltransferase. Several genes were significantly up- or down-regulated. Results provide insight into the molecular mechanism by which H4K20me3 contributes to gene expression. SUV420H2 stably over-expressing MDA-MB-231 cells were cloned. Then total RNA was extracted from the SUV420H2 over-expressing cells and the parental MDA-MB-231 cells.

ORGANISM(S): Homo sapiens

SUBMITTER: Satoshi Kondo

PROVIDER: E-GEOD-56912 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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SUV420H2 over-expression affects on gene expression in human breast cancer MDA-MB-231 cells

Project description:Analysis of breast cancer MDA-MB-231 cells stably over-expressing SUV420H2, a histone H4K20 methyltransferase. Several genes were significantly up- or down-regulated. Results provide insight into the molecular mechanism by which H4K20me3 contributes to gene expression. SUV420H2 stably over-expressing MDA-MB-231 cells were cloned. Then total RNA was extracted from the SUV420H2 over-expressing cells and the parental MDA-MB-231 cells.

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SUV420H2 over-expression affects on gene expression in human breast cancer MDA-MB-231 cells [MAA13355]

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SUV420H2 over-expression affects on gene expression in human breast cancer MDA-MB-231 cells

2015-04-15 | GSE55947 | GEO

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