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Gene expression profiles of induced cardiomyocytes(iCMs)

ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Homo sapiens

SUBMITTER: Satoshi Kondo

PROVIDER: E-GEOD-56913 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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MiR-133 promotes cardiac reprogramming by directly repressing Snai1 and silencing fibroblast signatures.

Muraoka Naoto N Yamakawa Hiroyuki H Miyamoto Kazutaka K Sadahiro Taketaro T Umei Tomohiko T Isomi Mari M Nakashima Hanae H Akiyama Mizuha M Wada Rie R Inagawa Kohei K Nishiyama Takahiko T Kaneda Ruri R Fukuda Toru T Takeda Shu S Tohyama Shugo S Hashimoto Hisayuki H Kawamura Yoshifumi Y Goshima Naoki N Aeba Ryo R Yamagishi Hiroyuki H Fukuda Keiichi K Ieda Masaki M

The EMBO journal 20140611 14

Fibroblasts can be directly reprogrammed into cardiomyocyte-like cells (iCMs) by overexpression of cardiac transcription factors or microRNAs. However, induction of functional cardiomyocytes is inefficient, and molecular mechanisms of direct reprogramming remain undefined. Here, we demonstrate that addition of miR-133a (miR-133) to Gata4, Mef2c, and Tbx5 (GMT) or GMT plus Mesp1 and Myocd improved cardiac reprogramming from mouse or human fibroblasts by directly repressing Snai1, a master regulat ...[more]

PMID: 24920580

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