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Regulatory consequences of TARBP2 over-expression in MDA-231 cell-line

ABSTRACT: Transient transfection of TARBP2 expression vectors (along with GFP controls) followed by transcriptomic profiling revealed that over-expression of TARBP2 resulted in a significant enrichment of sRSE-carrying transcripts among the down-regulated transcripts. Transient transfection of CMV-driven TARBP2 was used to over-express this protein in MDA-231 cells. The cells were then subjected to transcripome profiling in comparison to mock-transfected cells.

ORGANISM(S): Homo sapiens

SUBMITTER: Hani Goodarzi 

PROVIDER: E-GEOD-56948 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Metastasis-suppressor transcript destabilization through TARBP2 binding of mRNA hairpins.

Goodarzi Hani H   Zhang Steven S   Buss Colin G CG   Fish Lisa L   Tavazoie Saeed S   Tavazoie Sohail F SF  

Nature 20140709 7517

Aberrant regulation of RNA stability has an important role in many disease states. Deregulated post-transcriptional modulation, such as that governed by microRNAs targeting linear sequence elements in messenger RNAs, has been implicated in the progression of many cancer types. A defining feature of RNA is its ability to fold into structures. However, the roles of structural mRNA elements in cancer progression remain unexplored. Here we performed an unbiased search for post-transcriptional modula  ...[more]

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