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Dietary flaxseed- and radiation-sensitive microRNAs in murine lung

ABSTRACT: Murine lung miRNAs were profiled by rodent TaqMan OpenArray after flaxseed feeding and/or radiation exposure Lung tissue was obtained 48 hours after radiation or no exposure from three animals each: flaxseed/no radiation, flaxseed/radiation, control diet/no radiation, control diet/radiation. miRNA profiles were determined by OpenArray.

ORGANISM(S): Mus musculus

SUBMITTER: Kenneth Witwer

PROVIDER: E-GEOD-57123 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Dietary flaxseed modulates the miRNA profile in irradiated and non-irradiated murine lungs: a novel mechanism of tissue radioprotection by flaxseed.

Christofidou-Solomidou Melpo M Pietrofesa Ralph R Arguiri Evguenia E McAlexander Melissa A MA Witwer Kenneth W KW

Cancer biology & therapy 20140422 7

<h4>Introduction</h4>Dietary flaxseed (FS) displays antioxidant and anti-inflammatory properties in preclinical models of lung disease including radiation-induced pneumonopathy, however the mechanisms of lung radioprotection are incompletely understood. MicroRNAs (miRNAs) are short oligonucleotides that act as important posttranscriptional regulators of diverse networks including inflammatory response networks. Responses of miRNA profiles to diet and radiation exposure have been reported, but th ...[more]

PMID: 24755684

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