Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Timothy Reudelhuber
PROVIDER: E-GEOD-57239 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Xa Lucie K LK Lacombe Marie-Josée MJ Mercure Chantal C Lazure Claude C Reudelhuber Timothy L TL
American journal of physiology. Regulatory, integrative and comparative physiology 20140625 5
Renin, an aspartyl protease that catalyzes the rate-limiting step of the renin-angiotensin system, is first synthesized as an inactive precursor, prorenin. Prorenin is activated by the proteolytic removal of an amino terminal prosegment in the dense granules of the juxtaglomerular (JG) cells of the kidney by one or more proteases whose identity is uncertain but commonly referred to as the prorenin-processing enzyme (PPE). Because several extrarenal tissues secrete only prorenin, we tested the hy ...[more]