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Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of pooled human CD3+ cells in duplicate from healthy controls vs. patients with active chronic idiopathic thrombocytopenic purpura (ITP) and ITP in remission.

ABSTRACT: CD3+ cells were studied in duplicate from healthy controls, patients with active ITP and ITP in remission.

ORGANISM(S): Homo sapiens

DISEASE(S): active ITP

SUBMITTER: Bob Olsson

PROVIDER: E-GEOD-574 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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T-cell-mediated cytotoxicity toward platelets in chronic idiopathic thrombocytopenic purpura.

Olsson Bob B Andersson Per-Ola PO Jernås Margareta M Jacobsson Stefan S Carlsson Björn B Carlsson Lena M S LM Wadenvik Hans H

Nature medicine 20030824 9

Chronic idiopathic thrombocytopenic purpura (ITP) is a bleeding disorder that is characterized by increased platelet destruction and is believed to be autoantibody mediated. In this study, CD3+ T cells from ITP patients had increased expression of genes involved in cell-mediated cytotoxicity. In addition, cytotoxic cell-mediated lysis of autologous platelets was shown in active ITP. Our data suggest that T-cell-mediated cytotoxicity is an alternative mechanism for platelet destruction in ITP. ...[more]

PMID: 12937414

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