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Expression analysis of the effects of methyl-donor deficient diet on male mice (part 1)

ABSTRACT: BALB/c and CBA/Ca male mice were maintained for 8 weeks on a synthetic diet lacking in choline and folic acid and sacrificed after the end of dietary restrictions. The design of this study is further described in Voutounou, M., C .D. Glen, and Y. E. 2012. The effects of methyl-donor deficiency on mutation induction and transgenerational instability in mice. Mutat. Res. 734(1):1-4 (PMID: 22569175) The pattern of gene expression in spleen of mice sacrificed immediatelly after the end of dietary restrictions is not significatly altered. A six 12x135K chip study using total RNA extracted from kidney and liver of control and treated BALB/c male mice. The expression of 42,575 genes was measured with two-fold technical redundancy.

ORGANISM(S): Mus musculus

SUBMITTER: Yuri Dubrova

PROVIDER: E-GEOD-57521 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Expression analysis of the effects of methyl-donor deficient diet on male mice

Project description:BALB/c male mice were maintained for 8 weeks on a synthetic diet lacking in choline and folic acid and sacrificed 0, 2 and 6 weeks after the end of dietary restrictions. The design of this study is further described in Voutounou, M., C .D. Glen, and Y. E. 2012. The effects of methyl-donor deficiency on mutation induction and transgenerational instability in mice. Mutat. Res. 734(1):1-4 (PMID: 22569175) The pattern of gene expression in liver and kidney of mice sacrificed immediatelly after the end of dietary restrictions is significatly altered. A ten 12x135K chip study using total RNA extracted from kidney and liver of control and treated BALB/c male mice. The expression of 42,575 genes was measured with two-fold technical redundancy.

2012-12-13 | E-GEOD-42744 | biostudies-arrayexpress

Expression analysis of the effects of methyl-donor deficient diet on male mice (part 3)

Project description:CBA/Ca male mice were maintained for 8 weeks on a synthetic diet lacking in choline and folic acid and sacrificed 0 and 2 weeks after the end of dietary restrictions. The design of this study is further described in Voutounou, M., C .D. Glen, and Y. E. 2012. The effects of methyl-donor deficiency on mutation induction and transgenerational instability in mice. Mutat. Res. 734(1):1-4 (PMID: 22569175) The pattern of gene expression in liver of mice sacrificed immediatelly after the end of dietary restrictions is significatly altered. A ten 12x135K chip study using total RNA extracted from kidney and liver of control and treated BALB/c male mice. The expression of 42,575 genes was measured with two-fold technical redundancy.

2014-05-29 | E-GEOD-57523 | biostudies-arrayexpress

Expression analysis of the effects of methyl-donor deficient diet on male mice (part 2)

Project description:BALB/c male mice were maintained for 8 weeks on a synthetic diet lacking in choline and folic acid and mated with control females. Tissue samples were taken from eigth-week old male offspring of control and treated males. The design of this study is further described in Voutounou, M., C .D. Glen, and Y. E. 2012. The effects of methyl-donor deficiency on mutation induction and transgenerational instability in mice. Mutat. Res. 734(1):1-4 (PMID: 22569175) The pattern of gene expression in liver and kidney of mice sacrificed immediatelly after the end of dietary restrictions is significatly altered. A ten 12x135K chip study using total RNA extracted from kidney and liver of control and treated BALB/c male mice. The expression of 42,575 genes was measured with two-fold technical redundancy.

2014-05-29 | E-GEOD-57522 | biostudies-arrayexpress

Expression analysis of the effects of methyl-donor deficient diet on male mice (part 1)

Project description:BALB/c and CBA/Ca male mice were maintained for 8 weeks on a synthetic diet lacking in choline and folic acid and sacrificed after the end of dietary restrictions. The design of this study is further described in Voutounou, M., C .D. Glen, and Y. E. 2012. The effects of methyl-donor deficiency on mutation induction and transgenerational instability in mice. Mutat. Res. 734(1):1-4 (PMID: 22569175) The pattern of gene expression in spleen of mice sacrificed immediatelly after the end of dietary restrictions is not significatly altered.

2014-05-29 | GSE57521 | GEO

Expression analysis of the effects of methyl-donor deficient diet on male mice

2012-12-13 | GSE42744 | GEO

Expression analysis of the effects of methyl-donor deficient diet on male mice (part 3)

2014-05-29 | GSE57523 | GEO

Expression analysis of the effects of methyl-donor deficient diet on male mice (part 2)

2014-05-29 | GSE57522 | GEO

Expression analysis of the effects of methyl-donor deficient diet on male mice (parts 1 to 3)

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2014-05-29 | E-GEOD-57524 | biostudies-arrayexpress

Comparative gene-expression analysis on the first-generation offspring of irradiated male and female mice

Project description:Invstigation of whole genome gene expression level changes in kidney of the male offspring of BALB/c male and female mice exposed to 1 Gy of acute X-rays The design of this study is further described in Abouzeid Ali, H. E., R. C. Barber, and Y. E. Dubrova. 2012. The effects of maternal irradiation during adulthood on mutation induction and transgenerational instability in mice. Mutat. Res. 732(1): 21-25. (PMID: 22289278). A six 12x135K chip study using total RNA extracted from kidney of control and treated BALB/c male mice. The expression of 42,575 genes was measured with at least two-fold technical redundancy.

2013-01-29 | E-GEOD-42933 | biostudies-arrayexpress

Expression analysis of the first-generation offspring of irradiated male mice

Project description:Investigation of whole genome gene expression level changes in kidney, brain, liver and spleen of the offspring of CBA/Ca and BALB/c male mice exposed to 1 Gy of acute X-rays The pattern of gene expression of a number of circadian rhythm genes in the offspring of irradiated males is compromised A twenty-two 12x135K chip study using total RNA extracted from kidney, brain, liver and spleen of control CBA/Ca and BALB/c male mice and the first-generation offspring of male mice exposed to 1 Gy of acute X-rays. The expression of 42,575 genes was measured with two-fold technical redundancy.

2012-12-17 | E-GEOD-42621 | biostudies-arrayexpress

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