Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: WeiPing Chen
PROVIDER: E-GEOD-57716 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Modali Sita D SD Parekh Vaishali I VI Kebebew Electron E Agarwal Sunita K SK
Molecular endocrinology (Baltimore, Md.) 20150107 2
Biallelic inactivation of MEN1 encoding menin in pancreatic neuroendocrine tumors (PNETs) associated with the multiple endocrine neoplasia type 1 (MEN1) syndrome is well established, but how menin loss/inactivation initiates tumorigenesis is not well understood. We show that menin activates the long noncoding RNA maternally expressed gene 3 (Meg3) by histone-H3 lysine-4 trimethylation and CpG hypomethylation at the Meg3 promoter CRE site, to allow binding of the transcription factor cAMP respons ...[more]