Unknown,Transcriptomics,Genomics,Proteomics

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S100P is a metastasis-associated gene that facilitates transendothelial migration of pancreatic cancer cells [HG-U133_Plus_2]

ABSTRACT: We and others have shown that S100P is highly upregulated during the progression of pancreatic cancer. We used microarrays to look at the target genes regulated by S100P in the pancreatic cancer cell line Panc1. Keywords: Gene overexpression We generated stable cell lines by introducing control vector pcDNA3.1/V5-His or S100P-overexpressing vector pcDNA3.1/S100P-V5-His into the pancreatic cancer cell line Panc1, single cell clones were then isolated. RNA was extracted and hybridized on Affymetrix microarrays. We looked for new target genes regulated by S100P.

ORGANISM(S): Homo sapiens

SUBMITTER: Claude Chelala 

PROVIDER: E-GEOD-19278 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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S100P is a metastasis-associated gene that facilitates transendothelial migration of pancreatic cancer cells.

Barry Sayka S   Chelala Claude C   Lines Kate K   Sunamura Makoto M   Wang Amu A   Marelli-Berg Federica M FM   Brennan Caroline C   Lemoine Nicholas R NR   Crnogorac-Jurcevic Tatjana T  

Clinical & experimental metastasis 20120925 3

Pancreatic ductal adenocarcinoma (PDAC) is the 5th most common cause of cancer death in the UK and the 4th in the US. The vast majority of deaths following pancreatic cancer are due to metastatic spread, hence understanding the metastatic process is vital for identification of critically needed novel therapeutic targets. An enriched set of 33 genes differentially expressed in common between primary PDAC and liver metastases, when compared to normal tissues, was obtained through global gene expre  ...[more]

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