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Epigenome analysis of alcohol consumption in lymphocyte cell (LC) samples

ABSTRACT: Genome-wide DNA methylation profiling of individuals consuming alcohol and controls in LC samples. Individuals consuming alcohol were profiled at time of intake (T1) into treatment facility and four weeks into treatment (T2). Controls were profiled once. The Illumina Infinium 450k Human DNA Methylation BeadChip v1.0 was used to obtain DNA methylation profiles across 485,577 CpGs in LC samples. Samples included 33 case subjects at T1, 26 case subjects at T2 and 33 controls. Bisulfite-converted DNA from 92 samples were hybridized to the Illumina Infinium 450k Human Methylation BeadChip v1.0.

ORGANISM(S): Homo sapiens

SUBMITTER: Robert Philibert 

PROVIDER: E-GEOD-57853 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

A pilot examination of the genome-wide DNA methylation signatures of subjects entering and exiting short-term alcohol dependence treatment programs.

Philibert Robert A RA   Penaluna Brandan B   White Teresa T   Shires Sarah S   Gunter Tracy T   Liesveld Jill J   Erwin Cheryl C   Hollenbeck Nancy N   Osborn Terry T  

Epigenetics 20140811 9

Alcoholism has a profound impact on millions of people throughout the world. However, the ability to determine if a patient needs treatment is hindered by reliance on self-reporting and the clinician's capability to monitor the patient's response to treatment is challenged by the lack of reliable biomarkers. Using a genome-wide approach, we have previously shown that chronic alcohol use is associated with methylation changes in DNA from human cell lines. In this pilot study, we now examine DNA m  ...[more]

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