Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of C. elegans gene response to the pathogenic P. aeruginosa strain PA14.


ABSTRACT: Analysis of differential gene expression in C. elegans adults exposed to three different bacteria: E. coli strain OP50, wild-type P. aeruginosa PA14 and gacA mutant PA14. Samples were analyzed at 4 hours and 8 hours after exposure to the different bacteria. These studies identified C. elegans genes induced by pathogen infection. Experiment Overall Design: Three independent biological replicates were isolated for each treatment. All treatments were performed in parallel.

ORGANISM(S): Caenorhabditis elegans

SUBMITTER: Emily Troemel 

PROVIDER: E-GEOD-5793 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

p38 MAPK regulates expression of immune response genes and contributes to longevity in C. elegans.

Troemel Emily R ER   Chu Stephanie W SW   Reinke Valerie V   Lee Siu Sylvia SS   Ausubel Frederick M FM   Kim Dennis H DH  

PLoS genetics 20060911 11


The PMK-1 p38 mitogen-activated protein kinase pathway and the DAF-2-DAF-16 insulin signaling pathway control Caenorhabditis elegans intestinal innate immunity. pmk-1 loss-of-function mutants have enhanced sensitivity to pathogens, while daf-2 loss-of-function mutants have enhanced resistance to pathogens that requires upregulation of the DAF-16 transcription factor. We used genetic analysis to show that the pathogen resistance of daf-2 mutants also requires PMK-1. However, genome-wide microarra  ...[more]

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