Unknown,Transcriptomics,Genomics,Proteomics

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Characterizing the profiles of Ebf1 in mouse fat cells (ChIP-seq)


ABSTRACT: ChIP-seq data from mouse adipocyte. Mature 3T3-L1 adipocytes were cross-linked with 1% formaldehyde 10 days after induction with MDI. Frozen cell pellets were submitted to the Broad Institute for subsequent analysis of Ebf1-bound regions using anti-Ebf1 antibody (Abnova H00001879-M01).

ORGANISM(S): Mus musculus

SUBMITTER: Evan Rosen 

PROVIDER: E-GEOD-58330 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Early B-cell factor-1 (EBF1) is a key regulator of metabolic and inflammatory signaling pathways in mature adipocytes.

Griffin Michael J MJ   Zhou Yiming Y   Kang Sona S   Zhang Xiaolan X   Mikkelsen Tarjei S TS   Rosen Evan D ED  

The Journal of biological chemistry 20131030 50


EBF1 plays a crucial role in early adipogenesis; however, despite high expression in mature adipocytes, its function in these cells is currently unknown. To identify direct and indirect EBF1 targets in fat, we undertook a combination of transcriptional profiling of EBF1-deficient adipocytes and genome-wide EBF1 location analysis. Our results indicate that many components of metabolic and inflammatory pathways are positively and directly regulated by EBF1, including PI3K/AKT, MAPK, and STAT1 sign  ...[more]

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