Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Evan Rosen
PROVIDER: E-GEOD-58330 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Griffin Michael J MJ Zhou Yiming Y Kang Sona S Zhang Xiaolan X Mikkelsen Tarjei S TS Rosen Evan D ED
The Journal of biological chemistry 20131030 50
EBF1 plays a crucial role in early adipogenesis; however, despite high expression in mature adipocytes, its function in these cells is currently unknown. To identify direct and indirect EBF1 targets in fat, we undertook a combination of transcriptional profiling of EBF1-deficient adipocytes and genome-wide EBF1 location analysis. Our results indicate that many components of metabolic and inflammatory pathways are positively and directly regulated by EBF1, including PI3K/AKT, MAPK, and STAT1 sign ...[more]