Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of human tumor and stroma from breast catured by LCM of inflammatory and non inflammatory breast cancers


ABSTRACT: Tumor epithelium and surrounding stromal cells were isolated using laser capture microdissection of human breast cancer to examine differences in gene expression based on tissue types from inflammatory and non-inflammatory breast cancer Experiment Overall Design: We applied LCM to obtain samples enriched in tumor epithelium and stroma from 15 IBC and 35 non-IBC cases to study the relative contribution of each component to the IBC phenotype and to patient survival.

ORGANISM(S): Homo sapiens

SUBMITTER: Stefan Ambs 

PROVIDER: E-GEOD-5847 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

A stromal gene signature associated with inflammatory breast cancer.

Boersma Brenda J BJ   Reimers Mark M   Yi Ming M   Ludwig Joseph A JA   Luke Brian T BT   Stephens Robert M RM   Yfantis Harry G HG   Lee Dong H DH   Weinstein John N JN   Ambs Stefan S  

International journal of cancer 20080301 6


The factors that determine whether a breast carcinoma will develop into inflammatory breast cancer (IBC) remain poorly understood. Recent evidence indicates that the tumor stroma influences cancer phenotypes. We tested the hypotheses that the gene expression signature of the tumor stroma is a distinctive feature of IBC. We used laser capture microdissection to obtain enriched populations of tumor epithelial cells and adjacent stromal cells from 15 patients with IBC and 35 patients with invasive,  ...[more]

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