Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

Predicting Response and Survival in Chemotherapy-Treated Triple-Negative Breast Cancer

ABSTRACT: Gene expression data of pre-treatment samples of GEICAM2006-03 TNBC trial Patients were randomized to carboplatin or no carboplatin in the neoadjuvant setting In the study presented here, a well-defined cohort of 69 breast samples were used to acquire expression profiles of a total of 543 unique genes (+5 HK genes)

ORGANISM(S): Homo sapiens

SUBMITTER: Aleix Prat

PROVIDER: E-GEOD-58479 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Predicting response and survival in chemotherapy-treated triple-negative breast cancer.

Prat A A Lluch A A Albanell J J Barry W T WT Fan C C Chacón J I JI Parker J S JS Calvo L L Plazaola A A Arcusa A A Seguí-Palmer M A MA Burgues O O Ribelles N N Rodriguez-Lescure A A Guerrero A A Ruiz-Borrego M M Munarriz B B López J A JA Adamo B B Cheang M C U MC Li Y Y Hu Z Z Gulley M L ML Vidal M J MJ Pitcher B N BN Liu M C MC Citron M L ML Ellis M J MJ Mardis E E Vickery T T Hudis C A CA Winer E P EP Carey L A LA Caballero R R Carrasco E E Martín M M Perou C M CM Alba E E

British journal of cancer 20140807 8

<h4>Background</h4>In this study, we evaluated the ability of gene expression profiles to predict chemotherapy response and survival in triple-negative breast cancer (TNBC).<h4>Methods</h4>Gene expression and clinical-pathological data were evaluated in five independent cohorts, including three randomised clinical trials for a total of 1055 patients with TNBC, basal-like disease (BLBC) or both. Previously defined intrinsic molecular subtype and a proliferation signature were determined and teste ...[more]

PMID: 25101563

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Dataset Information

Predicting Response and Survival in Chemotherapy-Treated Triple-Negative Breast Cancer

Publications

Predicting response and survival in chemotherapy-treated triple-negative breast cancer.

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