Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

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Expression mRNA and miRNA data from human postmortem putamen samples measured using the NanoString nCounter platform


ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Homo sapiens

SUBMITTER: Venugopalan Nair 

PROVIDER: E-GEOD-77668 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Alterations of miRNAs reveal a dysregulated molecular regulatory network in Parkinson's disease striatum.

Nair Venugopalan D VD   Nair Venugopalan D VD   Ge Yongchao Y  

Neuroscience letters 20160629


Molecular adaptations in the striatum mediated by dopamine (DA) denervation and/or levodopa (L-dopa) treatments have been implicated in the motor deficits found in Parkinson's disease (PD). Alterations in inflammatory response mechanisms and glutamatergic neurotransmission are reported to play important roles in mediating these changes. However, the mechanisms mediating the molecular adaptations in the striatum are not well understood. Small non-coding microRNAs (miRNAs) influence numerous biolo  ...[more]

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