Unknown,Transcriptomics,Genomics,Proteomics

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Genome-wide transcriptome analyses by the RNA-seq method


ABSTRACT: We performed the whole transcriptome analysis in Zscan4 positive ES cells (Em+) and Zscan4 negative ES cells (Em-) by using FACS-sorted MC1-ZE7 ES cells. Whole RNA-seq in Zscan4 positive and negative cells

ORGANISM(S): Mus musculus

SUBMITTER: Minoru Ko 

PROVIDER: E-GEOD-58619 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Transient bursts of Zscan4 expression are accompanied by the rapid derepression of heterochromatin in mouse embryonic stem cells.

Akiyama Tomohiko T   Xin Li L   Oda Mayumi M   Sharov Alexei A AA   Amano Misa M   Piao Yulan Y   Cadet J Scotty JS   Dudekula Dawood B DB   Qian Yong Y   Wang Weidong W   Ko Shigeru B H SB   Ko Minoru S H MS  

DNA research : an international journal for rapid publication of reports on genes and genomes 20150831 5


Mouse embryonic stem cells (mESCs) have a remarkable capacity to maintain normal genome stability and karyotype in culture. We previously showed that infrequent bursts of Zscan4 expression (Z4 events) are important for the maintenance of telomere length and genome stability in mESCs. However, the molecular details of Z4 events remain unclear. Here we show that Z4 events involve unexpected transcriptional derepression in heterochromatin regions that usually remain silent. During a Z4 event, we se  ...[more]

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