Genomics

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ChIP-seq assays for H3K27ac


ABSTRACT: By using FACS-sorted MC1-ZE7 ES cells, we analyzed the genome-wide distribution of H3K27ac and DNA methylation in Zscan4 positive ES cells (Em+) and Zscan4 negative ES cells (Em-). H3K27 hyperacetylation and DNA demethylation were detected in heterochromatic regions of Em+ cells, but not Em- cells. These results suggested that the Zscan4 state takes "open" chromatin conformation in ES cells.

ORGANISM(S): Mus musculus

PROVIDER: GSE51679 | GEO | 2015/09/10

SECONDARY ACCESSION(S): PRJNA224548

REPOSITORIES: GEO

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