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Expression of milk miRNA during the lactation cycle of the marsupial tammar wallaby (Macropus eugenii)

ABSTRACT: High throughput sequencing of miRNAs collected from tammar milk at different time points of lactation showed high levels of miRNA secreted in milk and allowed the identification of differentially expressed milk miRNAs during the lactation cycle as putative markers of mammary gland activity and functional candidate signals to assist growth and timed development of the young. Comparative analysis of miRNA distribution in milk and blood serum suggests that milk miRNAs are primarily expressed from mammary gland rather than transferred from maternal circulating blood, likely through a new putative exosomal secretory pathway. 8 profiles were produced. Duplicates of day175

ORGANISM(S): Macropus eugenii

SUBMITTER: christophe lefevre

PROVIDER: E-GEOD-58941 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Differential temporal expression of milk miRNA during the lactation cycle of the marsupial tammar wallaby (Macropus eugenii).

Modepalli Vengamanaidu V Kumar Amit A Hinds Lyn A LA Sharp Julie A JA Nicholas Kevin R KR Lefevre Christophe C

BMC genomics 20141123

<h4>Background</h4>Lactation is a key aspect of mammalian evolution for adaptation of various reproductive strategies along different mammalian lineages. Marsupials, such as tammar wallaby, adopted a short gestation and a relatively long lactation cycle, the newborn is immature at birth and significant development occurs postnatally during lactation. Continuous changes of tammar milk composition may contribute to development and immune protection of pouch young. Here, in order to address the put ...[more]

PMID: 25417092

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Expression of milk miRNA during the lactation cycle of the marsupial tammar wallaby (Macropus eugenii)

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