Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of human Familial combined hyperlipidemia individuals exhibiting the USF1 susceptibility haplotype and FCHL affected indiviuals carrying the protective haplotype


ABSTRACT: Comparison of gene expression for individuals affected with FCHL exhibiting the USF1 susceptibility haplotype and FCHL affected indiviuals carrying the protective haplotype

ORGANISM(S): Homo sapiens

SUBMITTER: Massimiliano Gentile 

PROVIDER: E-GEOD-590 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications


Familial combined hyperlipidemia (FCHL), characterized by elevated levels of serum total cholesterol, triglycerides or both, is observed in about 20% of individuals with premature coronary heart disease. We previously identified a locus linked to FCHL on 1q21-q23 in Finnish families with the disease. This region has also been linked to FCHL in families from other populations as well as to type 2 diabetes mellitus. These clinical entities have several overlapping phenotypic features, raising the  ...[more]

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