Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Massimiliano Gentile
PROVIDER: E-GEOD-590 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Pajukanta Päivi P Lilja Heidi E HE Sinsheimer Janet S JS Cantor Rita M RM Lusis Aldons J AJ Gentile Massimiliano M Duan Xiaoqun Joyce XJ Soro-Paavonen Aino A Naukkarinen Jussi J Saarela Janna J Laakso Markku M Ehnholm Christian C Taskinen Marja-Riitta MR Peltonen Leena L
Nature genetics 20040229 4
Familial combined hyperlipidemia (FCHL), characterized by elevated levels of serum total cholesterol, triglycerides or both, is observed in about 20% of individuals with premature coronary heart disease. We previously identified a locus linked to FCHL on 1q21-q23 in Finnish families with the disease. This region has also been linked to FCHL in families from other populations as well as to type 2 diabetes mellitus. These clinical entities have several overlapping phenotypic features, raising the ...[more]