Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Ingrid Arijs
PROVIDER: E-GEOD-59071 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Inflammatory bowel diseases 20151101 11
<h4>Background</h4>Inflammatory bowel disease (IBD) is characterized by a chronic inflammation of the gut, partly driven by defects in the innate immune system. Considering the central role of inflammasome signaling in innate immunity, we studied inflammasome components in IBD mucosa.<h4>Methods</h4>Expression of genes encoding inflammasome sensor subunits was investigated in colonic mucosal biopsies from 2 cohorts of patients with IBD and controls.<h4>Results</h4>A significant upregulation (>2- ...[more]