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Microarray analysis of jejunal tissue from patients with Crohn's disease compared with non-inflammatory bowel disease patients

ABSTRACT: The entire small intestine was observed by balloon endoscopy. Biopsy specimens were taken from jejunum, ileum and colon, respectively. Four Crohn's disease patients and four healthy controls were compared.

ORGANISM(S): Homo sapiens

SUBMITTER: Kiichiro Tsuchiya

PROVIDER: E-GEOD-69762 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Reduced Human α-defensin 6 in Noninflamed Jejunal Tissue of Patients with Crohn's Disease.

Hayashi Ryohei R Tsuchiya Kiichiro K Fukushima Keita K Horita Nobukatsu N Hibiya Shuji S Kitagaki Keisuke K Negi Mariko M Itoh Eisaku E Akashi Takumi T Eishi Yoshinobu Y Okada Eriko E Araki Akihiro A Ohtsuka Kazuo K Fukuda Shinji S Ohno Hiroshi H Okamoto Ryuichi R Nakamura Tetsuya T Tanaka Shinji S Chayama Kazuaki K Watanabe Mamoru M

Inflammatory bowel diseases 20160501 5

<h4>Background</h4>Mucosal barrier dysfunction is considered a critical component of Crohn's disease (CD) pathogenesis after the identification of susceptibility genes. However, the precise mechanism underlying mucosal barrier dysfunction has not yet been elucidated. We therefore aimed to elucidate the molecular mechanism underlying the expression of human α-defensin 6 (HD6) in patients with CD.<h4>Methods</h4>HD6 expression was induced by the transfection of an atonal homolog 1 (Atoh1) transgen ...[more]

PMID: 26891258

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