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Expression data from Human Umbilical Vein Endothelial Cell after influenza virus infection

ABSTRACT: This research focus primarily on the interaction between influenza virus and endothelial cell, then we used microarrays to observe global patterns of gene expression in Human Umbilical Vein Endothelial Cells after influenza virus infection and offer further insight into the interaction between endothelial cells and influenza viruses. We used microarrays to detail the global programme of gene expression and identified distinct classes of up-regulated genes during this process. Human Umbilical Vein Endothelial Cells were selected at an early stage for RNA extraction and hybridization on Affymetrix microarrays. Then, we analysed the selected genes at expression level.

ORGANISM(S): Homo sapiens

SUBMITTER: Wei Wang

PROVIDER: E-GEOD-59226 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Expression data from Human Umbilical Vein Endothelial Cell after influenza virus infection

Project description:This research focus primarily on the interaction between influenza virus and endothelial cell, then we used microarrays to observe global patterns of gene expression in Human Umbilical Vein Endothelial Cells after influenza virus infection and offer further insight into the interaction between endothelial cells and influenza viruses. We used microarrays to detail the global programme of gene expression and identified distinct classes of up-regulated genes during this process.

2015-04-06 | GSE59226 | GEO

Oxidoreductase transcript data from human umbilical vein endothelial cells

Project description:Oxidoreductase enzymes are critical to redox regulation of intracellular proteins within human cells. We used microarrays to identify which oxidreducatse genes are expressed in unstimulated human umbilical vein endothelial cells. Human umbilical vein endothelial cells were grown under optimal conditions and then RNA extracted and hybridized on Affymetrix microarrays.

2010-06-16 | E-GEOD-22166 | biostudies-arrayexpress

Genome-wide analysis of miRNA-mRNA interactions in the marrow microenvironment (HTS)

Project description:We report genome-wide analysis of miRNA-mRNA interactions in the hematopoietic marrow microenvironment (ME) by employing the biochemical technique. High-throughput sequencing of RNA isolated by crosslinking immunoprecipitation or HITS-CLIP. Specifically, we analyzed 3 kinds of stromal cells (two human stromal cell lines named HS5 and HS27a and primary mesenchymal stromal cells (MSC) from normal donors) and two types of endothelial cells (TrBMEC, a human bone marrow endothelial cell line) and HUVEC (Human Umbilical Vein Endothelial Cells). Immune precipitation (IP) of Argonaut proteins (AGO1-4) was performed by anti-AGO monoclonal antibody 2A8. IP was performed on cells cross-linked by short-wave ultraviolet radiation (UV) 365 nM. Protocol was modified from as originally published by Chi et al Nature. 2009 Jul 23;460(7254):479-86.

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Expression data from HUVECs infected with influenza A virus PR8 and CA07

Project description:Using human umbilical vein endothelial cells (HUVECs) as cell models, the present study aims to explore the differential miRNAs in influenza virus-infected ECs and analyze their target genes involved in EC permeability regulation. As the results showed, permeability increased and F-actin cytoskeleton reorganized after HUVECs infected with influenza A virus (CA07 or PR8) at 30 MOI. most of these miRNAs were down-regulated after flu infection. It has been reported that PKC, Rho/ROCK, HRas/Raf/MEK/ERK, and Ca2+/CaM pathways are activated by flu infection and play important roles in permeability regulation.

2018-02-13 | GSE102866 | GEO

Homo sapiens

Project description:Expression data from Human Umbilical Vein Endothelial Cell after influenza virus infection

| PRJNA254761 | ENA

Rubella Virus wildtype and vaccine strains induce transcription of chemokines and components of innate immunity in human embryonic endothelial cells

Project description:We describe the transcriptional response to infection of human umbilical vein endothelial cells (Huvec) with different rubella virus strains

2022-08-31 | GSE192648 | GEO

Analysis of the early transcriptome signature of Nipah virus infection in primary endothelial cells

Project description:Nipah virus (NiV) is a recently emerged zoonotic Paramyxovirus that causes regular outbreaks in East Asia with mortality rate exceeding 75%. Major cellular targets of NiV infection are endothelial cells and neurons. To better understand virus-host interaction, we analysed the transcriptome profile of NiV infection in primary human umbilical vein endothelial cells. We found that NiV infection strongly induces genes involved in interferon response in endothelial cells. Among the top ten upregulated genes, we identified the chemokine CXCL10 (interferon-induced protein 10, IP-10), an important chemoattractant involved in the generation of inflammatory immune response and neurotoxicity. We performed microarray gene expression profiling of NiV infected HUVEC cell (2 replicates) and of uninfected HUVEC cell (2 replicates).

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Analysis of the early transcriptome signature of Nipah virus infection in primary endothelial cells

2012-08-24 | GSE32902 | GEO

Human endothelial cells stimulated with dengue virus non-structural protein 1

Project description:we report the changes in the transcriptome of human umbilical vein endothelial cells (HUVECS) after exposure to a recombinant purified soluble form of dengue virus non-structural protein 1 (NS1)

2020-06-04 | GSE139603 | GEO

Oxidoreductase transcript data from human umbilical vein endothelial cells

2010-06-05 | GSE22166 | GEO