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Genotyping of human breast cancer tumor samples (29), 4 normal samples and 8 lymphocytic samples

ABSTRACT: SNP Expression profiling of human breast cancer: 29 tumor samples, 4 pure normal breat samples and 8 lymphocytes samples Experiment Overall Design: In the operating theater, morphologically visible tumors were removed by surgery and examined by a surgical pathologist to confirm the presence of cancer cells by cryosections. The tissue samples were divided into discrete aliquots, flash frozen and subsequently stored in liquid nitrogen. Pure normal breast tissues are got from costmetic surgery and pure lymphocytes samples are from donators.

ORGANISM(S): Homo sapiens

SUBMITTER: wei chen 

PROVIDER: E-GEOD-5927 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

The identification of specific oncogenes and tumor suppressor genes in regions of recurrent aneuploidy is a major challenge of molecular cancer research. Using both oligonucleotide single-nucleotide polymorphism and mRNA expression arrays, we integrated genomic and transcriptional information to identify and prioritize candidate cancer genes in regions of increased and decreased chromosomal copy number in a cohort of primary breast cancers. Confirming the validity of this approach, several regio  ...[more]

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