Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Susanne Walz
PROVIDER: E-GEOD-59354 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Schülein-Völk Christina C Wolf Elmar E Zhu Jing J Xu Wenshan W Taranets Lyudmyla L Hellmann Andreas A Jänicke Laura A LA Diefenbacher Markus E ME Behrens Axel A Eilers Martin M Popov Nikita N
Cell reports 20141030 3
Fbw7, the substrate recognition subunit of SCF(Fbw7) ubiquitin ligase, mediates the turnover of multiple proto-oncoproteins and promotes its own degradation. Fbw7-dependent substrate ubiquitination is antagonized by the Usp28 deubiquitinase. Here, we show that Usp28 preferentially antagonizes autocatalytic ubiquitination and stabilizes Fbw7, resulting in dose-dependent effects in Usp28 knockout mice. Monoallelic deletion of Usp28 maintains stable Fbw7 but drives Fbw7 substrate degradation. In co ...[more]