Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Gail Mandel
PROVIDER: E-GEOD-59442 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
McGann James C JC Oyer Jon A JA Garg Saurabh S Yao Huilan H Liu Jun J Feng Xin X Liao Lujian L Yates John R JR Mandel Gail G
eLife 20140924
The bivalent hypothesis posits that genes encoding developmental regulators required for early lineage decisions are poised in stem/progenitor cells by the balance between a repressor histone modification (H3K27me3), mediated by the Polycomb Repressor Complex 2 (PRC2), and an activator modification (H3K4me3). In this study, we test whether this mechanism applies equally to genes that are not required until terminal differentiation. We focus on the RE1 Silencing Transcription Factor (REST) becaus ...[more]