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RNA editing by ADAR1 is essential for erythropoiesis [array]

ABSTRACT: Erythroid progenitors purified from EpoRCreR26eYFPADAR1fl/- and EpoRCreR26eYFPADAR1fl/+ control mice were compared for global gene array profiles Each sample was purified from one mouse

ORGANISM(S): Mus musculus

SUBMITTER: Alistair Chalk

PROVIDER: E-GEOD-59664 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Adenosine-to-inosine RNA editing by ADAR1 is essential for normal murine erythropoiesis.

Liddicoat Brian J BJ Hartner Jochen C JC Piskol Robert R Ramaswami Gokul G Chalk Alistair M AM Kingsley Paul D PD Sankaran Vijay G VG Wall Meaghan M Purton Louise E LE Seeburg Peter H PH Palis James J Orkin Stuart H SH Lu Jun J Li Jin Billy JB Walkley Carl R CR

Experimental hematology 20160701 10

Adenosine deaminases that act on RNA (ADARs) convert adenosine residues to inosine in double-stranded RNA. In vivo, ADAR1 is essential for the maintenance of hematopoietic stem/progenitors. Whether other hematopoietic cell types also require ADAR1 has not been assessed. Using erythroid- and myeloid-restricted deletion of Adar1, we demonstrate that ADAR1 is dispensable for myelopoiesis but is essential for normal erythropoiesis. Adar1-deficient erythroid cells display a profound activation of inn ...[more]

PMID: 27373493

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