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Gene expression analysis of Influenza vaccine response in Young and Old

ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Homo sapiens

SUBMITTER: Hailong Meng

PROVIDER: E-GEOD-59714 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Aging-dependent alterations in gene expression and a mitochondrial signature of responsiveness to human influenza vaccination.

Thakar Juilee J Mohanty Subhasis S West A Phillip AP Joshi Samit R SR Ueda Ikuyo I Wilson Jean J Meng Hailong H Blevins Tamara P TP Tsang Sui S Trentalange Mark M Siconolfi Barbara B Park Koonam K Gill Thomas M TM Belshe Robert B RB Kaech Susan M SM Shadel Gerald S GS Kleinstein Steven H SH Shaw Albert C AC

Aging 20150101 1

To elucidate gene expression pathways underlying age-associated impairment in influenza vaccine response, we screened young (age 21-30) and older (age≥65) adults receiving influenza vaccine in two consecutive seasons and identified those with strong or absent response to vaccine, including a subset of older adults meeting criteria for frailty. PBMCs obtained prior to vaccination (Day 0) and at day 2 or 4, day 7 and day 28 post-vaccine were subjected to gene expression microarray analysis. We def ...[more]

PMID: 25596819

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