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DNA methylation dynamics during ex vivo differentiation and maturation of human dendritic cells

ABSTRACT: Genomewide DNA methylation profiling of monocyte isolated from humna blood, immature and mature dendritic cells generated ex vivo. The Illumina Infinium HumanMethylation450 beadchips were used to generate DNA methylation profiles. Bisulfite converted DNA were hybridized to the Illumina Infinium HumanMethylation450 beadchips

ORGANISM(S): Homo sapiens

SUBMITTER: Hong Ji 

PROVIDER: E-GEOD-59796 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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DNA methylation dynamics during ex vivo differentiation and maturation of human dendritic cells.

Zhang Xue X   Ulm Ashley A   Somineni Hari K HK   Oh Sunghee S   Weirauch Matthew T MT   Zhang Hong-Xuan HX   Chen Xiaoting X   Lehn Maria A MA   Janssen Edith M EM   Ji Hong H  

Epigenetics & chromatin 20140820

<h4>Background</h4>Dendritic cells (DCs) are important mediators of innate and adaptive immune responses, but the gene networks governing their lineage differentiation and maturation are poorly understood. To gain insight into the mechanisms that promote human DC differentiation and contribute to the acquisition of their functional phenotypes, we performed genome-wide base-resolution mapping of 5-methylcytosine in purified monocytes and in monocyte-derived immature and mature DCs.<h4>Results</h4  ...[more]

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