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Ribosome profiling of harringtonine-treated SUM1315 cells

ABSTRACT: SUM1315 were treated with harringtonine, and an untreated control sample was taken. Ribosome profiling was performed on these samples. 1 treated and 1 untreated sample

ORGANISM(S): Homo sapiens

SUBMITTER: Koos Rooijers

PROVIDER: E-GEOD-59815 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Tumour-specific proline vulnerability uncovered by differential ribosome codon reading.

Loayza-Puch Fabricio F Rooijers Koos K Buil Levi C M LC Zijlstra Jelle J Oude Vrielink Joachim F JF Lopes Rui R Ugalde Alejandro Pineiro AP van Breugel Pieter P Hofland Ingrid I Wesseling Jelle J van Tellingen Olaf O Bex Axel A Agami Reuven R

Nature 20160215 7591

Tumour growth and metabolic adaptation may restrict the availability of certain amino acids for protein synthesis. It has recently been shown that certain types of cancer cells depend on glycine, glutamine, leucine and serine metabolism to proliferate and survive. In addition, successful therapies using L-asparaginase-induced asparagine deprivation have been developed for acute lymphoblastic leukaemia. However, a tailored detection system for measuring restrictive amino acids in each tumour is c ...[more]

PMID: 26878238

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