Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

Gene-expression profiles of BMP signaling-affected SK-OV-3 cells


ABSTRACT: Bone morphogenetic proteins (BMPs) are extracellular signaling molecules that belong to the transforming growth factor beta (TGF-β) superfamily. By regulating target gene transcription, BMPs control various cellular processes, such as proliferation, differentiation, apoptosis and migration. In addition, rBMP2 was used to observe BMP signaling in treatment of ovarian cancer cell line SK-OV-3. We attempted to address the possible roles of BMP signaling by inhibiting a wide-range of downstream pathways using a small molecule inhibitor of type I BMPRs, dorsomorphin. The potential utility of this molecule as a molecular inhibitor of BMP signaling in treatment of ovarian cancer cell line SK-OV-3 was also evaluated. SK-OV-3 cells were incubated in 12 separate culture dishes, 3 dishes with PBS, 3 dishes with recombinant BMP2 (rBMP2) (100 ng/ml), 3 dishes with DM (5 μM) and 3 dishes with recombinant BMP2 (rBMP2) (100 ng/ml) plus DM (5 μM) in the culture medium for 24 hours prior to the analysis.

ORGANISM(S): Homo sapiens

SUBMITTER: Jin Peng 

PROVIDER: E-GEOD-60135 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

Similar Datasets

2014-08-07 | GSE60135 | GEO
2012-03-29 | E-GEOD-36925 | biostudies-arrayexpress
2012-06-30 | E-GEOD-31792 | biostudies-arrayexpress
2011-11-11 | E-GEOD-33567 | biostudies-arrayexpress
| PRJNA257549 | ENA
2020-10-07 | GSE82106 | GEO
2011-11-10 | E-GEOD-32199 | biostudies-arrayexpress
2015-06-15 | E-MTAB-2495 | biostudies-arrayexpress
2010-06-10 | E-GEOD-2274 | biostudies-arrayexpress
2015-08-03 | E-GEOD-59567 | biostudies-arrayexpress