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Gene-expression profiles of BMP signaling-affected SK-OV-3 cells

ABSTRACT: Bone morphogenetic proteins (BMPs) are extracellular signaling molecules that belong to the transforming growth factor beta (TGF-β) superfamily. By regulating target gene transcription, BMPs control various cellular processes, such as proliferation, differentiation, apoptosis and migration. In addition, rBMP2 was used to observe BMP signaling in treatment of ovarian cancer cell line SK-OV-3. We attempted to address the possible roles of BMP signaling by inhibiting a wide-range of downstream pathways using a small molecule inhibitor of type I BMPRs, dorsomorphin. The potential utility of this molecule as a molecular inhibitor of BMP signaling in treatment of ovarian cancer cell line SK-OV-3 was also evaluated.

ORGANISM(S): Homo sapiens

PROVIDER: GSE60135 | GEO | 2014/08/07

SECONDARY ACCESSION(S): PRJNA257549

REPOSITORIES: GEO

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