Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Danny Reinberg
PROVIDER: E-GEOD-60227 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Narendra Varun V Rocha Pedro P PP An Disi D Raviram Ramya R Skok Jane A JA Mazzoni Esteban O EO Reinberg Danny D
Science (New York, N.Y.) 20150201 6225
Polycomb and Trithorax group proteins encode the epigenetic memory of cellular positional identity by establishing inheritable domains of repressive and active chromatin within the Hox clusters. Here we demonstrate that the CCCTC-binding factor (CTCF) functions to insulate these adjacent yet antagonistic chromatin domains during embryonic stem cell differentiation into cervical motor neurons. Deletion of CTCF binding sites within the Hox clusters results in the expansion of active chromatin into ...[more]