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The pH-sensing receptor OGR1 improves barrier function of CaCo-2 cells and inhibits migration in an acidic environment

ABSTRACT: OGR1 is a pH-sensing G-protein coupled receptor involved in intestinal homeostasis and inflammation Proton activation of OGR1 increases barrier function in Caco2 cells Microarray profiling was performed on OGR1 stable overexpressing Caco-2 cells during acidic pH shift

ORGANISM(S): Homo sapiens

SUBMITTER: Cheryl de Valliere

PROVIDER: E-GEOD-60294 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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The pH-sensing receptor OGR1 improves barrier function of epithelial cells and inhibits migration in an acidic environment.

de Vallière Cheryl C Vidal Solange S Clay Ieuan I Jurisic Giorgia G Tcymbarevich Irina I Lang Silvia S Ludwig Marie-Gabrielle MG Okoniewski Michal M Eloranta Jyrki J JJ Kullak-Ublick Gerd A GA Wagner Carsten A CA Rogler Gerhard G Seuwen Klaus K

American journal of physiology. Gastrointestinal and liver physiology 20150723 6

The pH-sensing receptor ovarian cancer G protein-coupled receptor 1 (OGR1; GPR68) is expressed in the gut. Inflammatory bowel disease is typically associated with a decrease in local pH, which may lead to altered epithelial barrier function and subsequent gastrointestinal repair involving epithelial cell adhesion and migration. As the mechanisms underlying the response to pH changes are not well understood, we have investigated OGR1-mediated, pH-dependent signaling pathways in intestinal epithel ...[more]

PMID: 26206859

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The G protein-coupled pH-sensing receptor OGR1 is a regulator of intestinal inflammation

Project description:OGR1 is a pH sensing G protein-coupled receptor involved in intestinal homeostasis and inflammation. Up-regulation of genes, mediated by OGR1, in response to extracellular acidification were enriched for inflammation, immune response, actin cytoskeleton and cell adhesion pathways. Microarray profiling was performed to compare global gene expression of Ogr1 KO and WT residential peritoneal macrophages in response to an acidic pH shift (pH 6.7, 24 h)

2015-04-12 | E-GEOD-60295 | biostudies-arrayexpress

The pH-sensing receptor OGR1 improves barrier function of CaCo-2 cells and inhibits migration in an acidic environment

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Microarray-based gene expression data from BPLER tumor explants.

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