Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Catherine Schuster
PROVIDER: E-GEOD-60374 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Majzoub Karim K Hafirassou Mohamed Lamine ML Meignin Carine C Goto Akira A Marzi Stefano S Fedorova Antonina A Verdier Yann Y Vinh Joëlle J Hoffmann Jules A JA Martin Franck F Baumert Thomas F TF Schuster Catherine C Imler Jean-Luc JL
Cell 20141101 5
Fighting viral infections is hampered by the scarcity of viral targets and their variability, resulting in development of resistance. Viruses depend on cellular molecules-which are attractive alternative targets-for their life cycle, provided that they are dispensable for normal cell functions. Using the model organism Drosophila melanogaster, we identify the ribosomal protein RACK1 as a cellular factor required for infection by internal ribosome entry site (IRES)-containing viruses. We further ...[more]