Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Golnaz Vahedi
PROVIDER: E-GEOD-60482 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Vahedi Golnaz G Kanno Yuka Y Furumoto Yasuko Y Jiang Kan K Parker Stephen C J SC Erdos Michael R MR Davis Sean R SR Roychoudhuri Rahul R Restifo Nicholas P NP Gadina Massimo M Tang Zhonghui Z Ruan Yijun Y Collins Francis S FS Sartorelli Vittorio V O'Shea John J JJ
Nature 20150216 7548
Enhancers regulate spatiotemporal gene expression and impart cell-specific transcriptional outputs that drive cell identity. Super-enhancers (SEs), also known as stretch-enhancers, are a subset of enhancers especially important for genes associated with cell identity and genetic risk of disease. CD4(+) T cells are critical for host defence and autoimmunity. Here we analysed maps of mouse T-cell SEs as a non-biased means of identifying key regulatory nodes involved in cell specification. We found ...[more]