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Transcription profiling of mouse wild type or Batf deficient T cells cultured under various combinations of IL-6 orTGF-beta

ABSTRACT: Wild type and Batf deficient T cells were stimulated under various combinations of IL-6 or TGF-beta.

ORGANISM(S): Mus musculus

SUBMITTER: Barbara Schraml

PROVIDER: E-MEXP-2152 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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The AP-1 transcription factor Batf controls T(H)17 differentiation.

Schraml Barbara U BU Hildner Kai K Ise Wataru W Lee Wan-Ling WL Smith Whitney A-E WA Solomon Ben B Sahota Gurmukh G Sim Julia J Mukasa Ryuta R Cemerski Saso S Hatton Robin D RD Stormo Gary D GD Weaver Casey T CT Russell John H JH Murphy Theresa L TL Murphy Kenneth M KM

Nature 20090705 7253

Activator protein 1 (AP-1, also known as JUN) transcription factors are dimers of JUN, FOS, MAF and activating transcription factor (ATF) family proteins characterized by basic region and leucine zipper domains. Many AP-1 proteins contain defined transcriptional activation domains, but BATF and the closely related BATF3 (refs 2, 3) contain only a basic region and leucine zipper, and are considered to be inhibitors of AP-1 activity. Here we show that Batf is required for the differentiation of IL ...[more]

PMID: 19578362

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2010-08-31 | E-GEOD-23505 | biostudies-arrayexpress

Dynamic BRG1 Recruitment During T Helper Differentiation And Activation Reveals Distal Regulatory Elements

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2013-06-27 | E-GEOD-45975 | biostudies-arrayexpress

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2014-02-13 | E-GEOD-54938 | biostudies-arrayexpress

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