Systems Analysis of a RIG-I Agonist Inducing Broad Spectrum Inhibition of Virus Infectivity
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: John Hiscott
PROVIDER: E-GEOD-60574 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Systems analysis of a RIG-I agonist inducing broad spectrum inhibition of virus infectivity.
Goulet Marie-Line ML Olagnier David D Xu Zhengyun Z Paz Suzanne S Belgnaoui S Mehdi SM Lafferty Erin I EI Janelle Valérie V Arguello Meztli M Paquet Marilene M Ghneim Khader K Richards Stephanie S Smith Andrew A Wilkinson Peter P Cameron Mark M Kalinke Ulrich U Qureshi Salman S Lamarre Alain A Haddad Elias K EK Sekaly Rafick Pierre RP Peri Suraj S Balachandran Siddharth S Lin Rongtuan R Hiscott John J
PLoS pathogens 20130425 4
The RIG-I like receptor pathway is stimulated during RNA virus infection by interaction between cytosolic RIG-I and viral RNA structures that contain short hairpin dsRNA and 5' triphosphate (5'ppp) terminal structure. In the present study, an RNA agonist of RIG-I was synthesized in vitro and shown to stimulate RIG-I-dependent antiviral responses at concentrations in the picomolar range. In human lung epithelial A549 cells, 5'pppRNA specifically stimulated multiple parameters of the innate antivi ...[more]
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