A subcutaneous adipose tissue-liver axis in the control of hepatic gluconeogenesis
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Ruth Yu
PROVIDER: E-GEOD-57054 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
A subcutaneous adipose tissue-liver signalling axis controls hepatic gluconeogenesis.
Reilly Shannon M SM Ahmadian Maryam M Zamarron Brian F BF Chang Louise L Uhm Maeran M Poirier BreAnne B Peng Xiaoling X Krause Danielle M DM Korytnaya Evgenia E Neidert Adam A Liddle Christopher C Yu Ruth T RT Lumeng Carey N CN Oral Elif A EA Downes Michael M Evans Ronald M RM Saltiel Alan R AR
Nature communications 20150112
The search for effective treatments for obesity and its comorbidities is of prime importance. We previously identified IKK-ε and TBK1 as promising therapeutic targets for the treatment of obesity and associated insulin resistance. Here we show that acute inhibition of IKK-ε and TBK1 with amlexanox treatment increases cAMP levels in subcutaneous adipose depots of obese mice, promoting the synthesis and secretion of the cytokine IL-6 from adipocytes and preadipocytes, but not from macrophages. IL- ...[more]
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