Ontology highlight
ABSTRACT:
ORGANISM(S): Rattus norvegicus
SUBMITTER: Pavel Baranov
PROVIDER: E-GEOD-60752 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Andreev Dmitry E DE O'Connor Patrick B F PB Zhdanov Alexander V AV Dmitriev Ruslan I RI Shatsky Ivan N IN Papkovsky Dmitri B DB Baranov Pavel V PV
Genome biology 20150506
<h4>Background</h4>Oxygen and glucose metabolism play pivotal roles in many (patho)physiological conditions. In particular, oxygen and glucose deprivation (OGD) during ischemia and stroke results in extensive tissue injury and cell death.<h4>Results</h4>Using time-resolved ribosome profiling, we assess gene expression levels in a neural cell line, PC12, during the first hour of OGD. The most substantial alterations are seen to occur within the first 20 minutes of OGD. While transcription of only ...[more]