Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Supat Thongjuea
PROVIDER: E-GEOD-62741 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Buono Mario M Facchini Raffaella R Matsuoka Sahoko S Thongjuea Supat S Waithe Dominique D Luis Tiago C TC Giustacchini Alice A Besmer Peter P Mead Adam J AJ Jacobsen Sten Eirik W SE Nerlov Claus C
Nature cell biology 20160118 2
Thymic T cell development is initiated from bone-marrow-derived multi potent thymus-seeding progenitors. During the early stages of thymocyte differentiation, progenitors become T cell restricted. However, the cellular environments supporting these critical initial stages of T cell development within the thymic cortex are not known. Here we use the dependence of early, c-Kit-expressing thymic progenitors on Kit ligand (KitL) to show that CD4(-)CD8(-)c-Kit(+)CD25(-) DN1-stage progenitors associat ...[more]